乳腺癌
医学
免疫组织化学
阶段(地层学)
肿瘤科
内科学
生物标志物
癌症
三阴性乳腺癌
乳腺癌
浸润性导管癌
临床意义
病理
生物
古生物学
生物化学
作者
Joo Heon Kim,Tae-Hwa Baek,Hyun Sun Yim,Kyo Hyun Kim,Seong-Hoo Jeong,Ho Bum Kang,Sang-Ho Oh,Hee Gu Lee,Jae Wha Kim,Kwang Dong Kim
出处
期刊:Pathology & Oncology Research
[Frontiers Media SA]
日期:2013-05-09
卷期号:19 (4): 731-737
被引量:49
标识
DOI:10.1007/s12253-013-9636-y
摘要
CTHRC1 has been known as a regulator of collagen expression and cell migration. The aim of this research was to clarify the clinicopathologic significance of CTHRC1 expression in human breast cancer. 22 cases of breast cancer tissues, randomly selected from clinically diagnosed patients, showed a significant increase of CTHRC1 mRNA expression compared to the normal tissue from the same patients using RT-PCR and real-time PCR. Additionally we investigated breast cancers from 189 patients by immunohistochemistry (IHC). A high level of CTHRC1 expression was observed in 111 (58.7 %) out of 189 breast cancer patients and the expression was significantly correlated with histologic grade (P = 0.026), nodal status (P < 0.001), and TNM pathologic stage (P = 0.002). High CTHRC1 expression was associated with a shorter recurrence free survival (P = 0.008). Taken together, the results showed that CTHRC1 over-expression was significantly associated with clinicopathological factors of poor prognosis in invasive ductal carcinoma. CTHRC1 could be used as a supplementary prognostic biomarker and a potential therapeutic target in breast cancer.
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