化学
寻常变形杆菌
抗菌剂
福氏志贺氏菌
黑曲霉
白色念珠菌
蜡样芽孢杆菌
烟曲霉
苯并咪唑
抗细菌
微生物学
抗菌活性
细菌
大肠杆菌
结核分枝杆菌
有机化学
生物
生物化学
肺结核
病理
基因
医学
遗传学
作者
Rahul V. Patel,Paresh K. Patel,Premlata Kumari,Dhanji P. Rajani,Kishor H. Chikhalia
标识
DOI:10.1016/j.ejmech.2012.03.033
摘要
To affiliate multiple bioactivities in a compact heteronuclei, two series of benzimidazole based 1,3,4-oxadiazoles were synthesized and assessed in vitro for their efficacy as antimicrobial agents against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella flexneri), four fungi (Aspergillus niger, Aspergillus fumigatus, Aspergillus clavatus, Candida albicans) and Mycobacterium tuberculosis H37Rv and best results were observed amongst the N-benzothiazolyl aetamide series. The lipophilicity (LogP) influence on the biological profile (MICs) of the prepared products was also discussed. Upon biological screening, it was observed that the majority of the compounds were found to possess a significant broad spectrum antimicrobial (3.12-25 μg/mL of MIC) and antitubercular (6.25-25 μg/mL of MIC) potential. The structural assignments of the new products were done on the basis of IR, (1)H NMR, (13)C NMR spectroscopy and elemental analysis.
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