先天性淋巴细胞
获得性免疫系统
生物
免疫系统
先天免疫系统
免疫学
细胞生物学
免疫
白细胞介素15
T细胞
白细胞介素12
白细胞介素
细胞因子
细胞毒性T细胞
体外
生物化学
作者
Wendy T. Watford,Masato Moriguchi,Akio Morinobu,John J. O’Shea
标识
DOI:10.1016/s1359-6101(03)00043-1
摘要
Cytokines play critical roles in regulating all aspects of immune responses, including lymphoid development, homeostasis, differentiation, tolerance and memory. Interleukin (IL)-12 is especially important because its expression during infection regulates innate responses and determines the type and duration of adaptive immune response. IL-12 induces interferon-gamma (IFN-gamma) production by NK, T cells, dendritic cells (DC), and macrophages. IL-12 also promotes the differentiation of naïve CD4+ T cells into T helper 1 (Th1) cells that produce IFN-gamma and aid in cell-mediated immunity. As IL-12 is induced by microbial products and regulates the development of adaptive immune cells, IL-12 plays a central role in coordinating innate and adaptive immunity. IL-12 and the recently identified cytokines, IL-23 and IL-27, define a family of related cytokines that induce IFN-gamma production and promote T cell expansion and proliferation.
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