立体中心
对映选择合成
四氢异喹啉
催化作用
化学
组合化学
配体(生物化学)
铜
立体化学
有机化学
受体
生物化学
作者
Weimin Lin,Tao Cao,Fan Wu,Ying‐Feng Han,Junqi Kuang,Hongwen Luo,Bo Miao,Xinjun Tang,Qiong Yu,Weiming Yuan,Jiasheng Zhang,Can Zhu,Shengming Ma
标识
DOI:10.1002/anie.201308699
摘要
Tetrahydroisoquinoline alkaloids with a C1 stereogenic center are a common unit in many natural and non-natural compounds of biological importance. Herein we describe a novel Cu(I) -catalyzed highly chemo- and enantioselective synthesis of chiral tetrahydroisoquinoline-alkaloid derivatives from readily available unsubstituted tetrahydroisoquinolines, aldehydes, and terminal alkynes in the presence of the ligand (R,R)-N-pinap. This synthetic operation installs two substituents in the 1- and 2-positions.
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