陶氏病
神经科学
转基因小鼠
转基因
认知
神经退行性变
心理学
生物
医学
疾病
病理
基因
生物化学
作者
Karen S. SantaCruz,Jada Lewis,Tara L. Spires,Jennifer Paulson,Linda Kotilinek,Martin Ingelsson,Aaron Guimaraes,Michael DeTure,Martin Ramsden,Eileen McGowan,Colleen L. Forster,Mei Yue,Jennifer D. Orne,Christopher Janus,Ami Mariash,Michael A. Kuskowski,Bradley T. Hyman,Michael Hutton,Karen H. Ashe
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2005-07-15
卷期号:309 (5733): 476-481
被引量:1781
标识
DOI:10.1126/science.1113694
摘要
Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuronal death and cognitive deficits. Here, we found that mice expressing a repressible human tau variant developed progressive age-related NFTs, neuronal loss, and behavioral impairments. After the suppression of transgenic tau, memory function recovered, and neuron numbers stabilized, but to our surprise, NFTs continued to accumulate. Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy.
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