Formation of Sequence‐Independent Z‐DNA Induced by a Ruthenium Complex at Low Salt Concentrations

Switched: The metal complex [Ru(dip)2dppz]2+ can induce the transition from B-DNA to Z-DNA and stabilize the Z conformation in aqueous low-salt solution (see scheme; dip=4,7-diphenyl-1,10-phenanthroline, dppz=dipyridophenazine). The transition is sequence-independent (including non-alternating pyrimidine–purine and AT-rich sequences) and was monitored by CD and 2D NMR spectroscopy, AFM, isothermal titration calorimetry, and gel electrophoresis. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.