毒力
生物
微生物学
基因座(遗传学)
基因组岛
基因
猪链球菌
遗传学
基因组
比较基因组学
基因组学
作者
Zongfu Wu,Weixue Wang,Min Tang,Jing Shao,Chen Dai,Wei Zhang,Hongjie Fan,Huochun Yao,Jie Zong,Caili Dai,Junning Wang,Lu Chen
出处
期刊:Gene
[Elsevier]
日期:2014-02-01
卷期号:535 (2): 156-164
被引量:39
标识
DOI:10.1016/j.gene.2013.11.044
摘要
Streptococcus suis (SS) is an important swine pathogen worldwide that occasionally causes serious infections in humans. SS infection may result in meningitis in pigs and humans. The pathogenic mechanisms of SS are poorly understood. Here, we provide the complete genome sequence of S. suis serotype 2 (SS2) strain SC070731 isolated from a pig with meningitis. The chromosome is 2,138,568bp in length. There are 1933 predicted protein coding sequences and 96.7% (57/59) of the known virulence-associated genes are present in the genome. Strain SC070731 showed similar virulence with SS2 virulent strains HA9801 and ZY05719, but was more virulent than SS2 virulent strain P1/7 in the zebrafish infection model. Comparative genomic analysis revealed a unique 105K genomic island in strain SC070731 that is absent in seven other sequenced SS2 strains. Further analysis of the 105K genomic island indicated that it contained a complete nisin locus similar to the nisin U locus in S. uberis strain 42, a prophage similar to S. oralis phage PH10 and several antibiotic resistance genes. Several proteins in the 105K genomic island, including nisin and RelBE toxin-antitoxin system, contribute to the bacterial fitness and virulence in other pathogenic bacteria. Further investigation of newly identified gene products, including four putative new virulence-associated surface proteins, will improve our understanding of SS pathogenesis.
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