Enantioselective Mannich Reaction Employing 1,3,5‐Triaryl‐1,3,5‐triazinanes Catalyzed by Chiral‐at‐Metal Rhodium Complexes

Chiral‐at‐metal Rh III complexes catalyze the efficient enantioselective Mannich reaction of 2‐acyl imidazoles with 1,3,5‐triazinanes, affording the corresponding adducts in 81–99 % yield with up to >99 % enantioselectivity. This protocol performs with 0.1 mol‐% of Rh III complex on gram scale without any loss in enantioselectivity.