计算机科学
极限(数学)
功能(生物学)
生化工程
序列(生物学)
系统工程
计算生物学
工程类
生物
数学
遗传学
数学分析
作者
Emanuele Monza,Víctor Gil,María Lucas
出处
期刊:Methods in molecular biology
日期:2021-11-24
卷期号:: 249-259
标识
DOI:10.1007/978-1-0716-1826-4_13
摘要
Directed evolution is the most recognized methodology for enzyme engineering. The main drawback resides in its random nature and in the limited sequence exploration; both require screening of thousands (if not millions) of variants to achieve a target function. Computer-driven approaches can limit laboratorial screening to a few hundred candidates, enabling and accelerating the development of industrial enzymes. In this book chapter, the technology adopted at Zymvol is described. An overview of the current development and future directions in the company is also provided.
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