颗粒(地质)
血小板
化学
止血
趋化因子
P-选择素
血管生成
血小板因子4
分泌物
血小板活化
致密颗粒
炎症
生物化学
细胞生物学
免疫学
癌症研究
生物
医学
内科学
古生物学
出处
期刊:Platelets
[Informa]
日期:2021-09-25
卷期号:33 (4): 491-502
被引量:13
标识
DOI:10.1080/09537104.2021.1913576
摘要
Upon activation, platelets release a plethora of factors which help to mediate their dynamic functions in hemostasis, inflammation, wound healing, tumor metastasis and angiogenesis. The majority of these bioactive molecules are released from α-granules, which are unique to platelets, and contain an incredibly diverse repertoire of cargo including; integral membrane proteins, pro-coagulant molecules, chemokines, mitogenic, growth and angiogenic factors, adhesion proteins, and microbicidal proteins. Clinically, activation of circulating platelets has increasingly been associated with various disease states. Biomarkers indicating the level of platelet activation in patients can therefore be useful tools to evaluate risk factors to predict future complications and determine treatment strategies or evaluate antiplatelet therapy. The irreversible nature of α-granule secretion makes it ideally suited as a marker of platelet activation. This review outlines the release and contents of platelet α-granules, as well as the membrane bound, and soluble α-granule cargo proteins that can be used as biomarkers of platelet activation.
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