自噬
PI3K/AKT/mTOR通路
蛋白激酶B
肺癌
信号转导
表皮生长因子受体
癌症研究
背景(考古学)
生物
RPTOR公司
癌症
医学
细胞生物学
肿瘤科
内科学
细胞凋亡
生物化学
古生物学
作者
Jing Wang,Mei Gong,Xirong Fan,Dalu Huang,Jinshu Zhang,Cheng Huang
标识
DOI:10.1007/s11010-021-04280-5
摘要
Lung cancer is one of the most prevalent causes of morbidity and mortality in both men and women across the globe. The disease has a quiet phenotype at first, which leads to chronic tumor development. Non-small cell lung cancer (NSCLC) is the most common kind of lung cancer, accounting for 85 percent of all lung malignancies. Autophagy has been described as an intracellular “recycle bin” where damaged proteins and molecules are degraded. Autophagy regulation is mainly dependent on signaling pathways such as phosphoinositide 3-kinases (PI3K), AKT, and the mammalian target of rapamycin (mTOR). In the context of NSCLC, studies on these signaling pathways are inconsistent, but our literature review suggests that the inhibition of mTOR, PI3K/AKT, and epidermal growth factor receptor signaling pathways by different medications can active autophagy and inhibit NSCLC progression. In conclusion, signaling pathways related to autophagy are effective therapeutic approaches for the treatment of NSCLC.
科研通智能强力驱动
Strongly Powered by AbleSci AI