再生(生物学)
脚手架
脊髓损伤
轴突
神经科学
病变
脊髓
神经突
胶质瘢痕
生物医学工程
解剖
医学
生物
细胞生物学
病理
体外
生物化学
作者
Dingyang Liu,He Shen,Yeyu Shen,Ge Long,Xinghui He,Yannan Zhao,Zhiquan Yang,Jianwu Dai,Xing Li
标识
DOI:10.1002/adhm.202100089
摘要
Abstract Complete transection spinal cord injury (SCI) severely disrupts the integrity of both neural circuits and the microvasculature system. Hence, fabricating a functional bio‐scaffold that could coordinate axonal regeneration and vascular reconstruction in the lesion area may emerge as a new paradigm for complete SCI repair. In this study, a photosensitive hydrogel scaffold loaded with collagen‐binding stromal cell‐derived factor‐1a and Taxol liposomes is capable of inducing migration of endothelial cells and promoting neurite outgrowth of neurons in vitro. In addition, when implanted into a rat T8 complete transection SCI model, the above dual‐cues laden scaffold exhibits a synergistic effect on facilitating axon and vessel regeneration in the lesion area within 10 days after injury. Moreover, long‐term therapeutic effects are also observed after dual‐cues laden scaffold implantation, including revascularization, descending and propriospinal axonal regeneration, fibrotic scar reduction, electrophysiological recovery, and motor function improvement. In summary, the dual‐cues laden scaffold has good clinical application potential for patients with severe SCI.
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