肿瘤微环境
内皮干细胞
纳米颗粒
纳米技术
肿瘤细胞
癌症研究
细胞生物学
化学
生物物理学
材料科学
生物
体外
生物化学
作者
Benjamin R. Kingston,Zachary P. Lin,Ben Ouyang,Presley MacMillan,Jessica Ngai,Abdullah M. Syed,Shrey Sindhwani,Warren C. W. Chan
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-08-12
卷期号:15 (9): 14080-14094
被引量:65
标识
DOI:10.1021/acsnano.1c04510
摘要
The successful delivery of nanoparticles to solid tumors depends on their ability to pass through blood vessels and into the tumor microenvironment. Here, we discovered a subset of tumor endothelial cells that facilitate nanoparticle transport into solid tumors. We named these cells nanoparticle transport endothelial cells (N-TECs). We show that only 21% of tumor endothelial cells located on a small number of vessels are involved in transporting nanoparticles into the tumor microenvironment. N-TECs have an increased expression of genes related to nanoparticle transport and vessel permeability compared to other tumor endothelial cells. The N-TECs act as gatekeepers that determine the entry point, distribution, cell accessibility, and number of nanoparticles that enter the tumor microenvironment.
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