In this review article we provide an overview of epigenetic markers associated with the effects of particulate matter with different aerodynamic diameters, namely, PM0,1, PM, PM10 and PM2,5-10. The developed list of more than 150 epigenetic signatures of environmental pollutants on different human health conditions may contribute to the development of novel methodological approaches to early detection of diseases in individuals exposed to particulate matter. In addition, this work can become a prerequisite for the development of fundamentally new air purification systems.