口渴
穹窿下器官
光遗传学
神经科学
下丘脑
刺激(心理学)
人口
室周器官
生物
内分泌学
心理学
医学
环境卫生
血压
肾素-血管紧张素系统
心理治疗师
作者
Yuki Oka,Mingyu Ye,Charles S. Zuker
出处
期刊:Nature
[Springer Nature]
日期:2015-01-26
卷期号:520 (7547): 349-352
被引量:199
摘要
Thirst is the basic instinct to drink water. Previously, it was shown that neurons in several circumventricular organs of the hypothalamus are activated by thirst-inducing conditions. Here we identify two distinct, genetically separable neural populations in the subfornical organ that trigger or suppress thirst. We show that optogenetic activation of subfornical organ excitatory neurons, marked by the expression of the transcription factor ETV-1, evokes intense drinking behaviour, and does so even in fully water-satiated animals. The light-induced response is highly specific for water, immediate and strictly locked to the laser stimulus. In contrast, activation of a second population of subfornical organ neurons, marked by expression of the vesicular GABA transporter VGAT, drastically suppresses drinking, even in water-craving thirsty animals. These results reveal an innate brain circuit that can turn an animal's water-drinking behaviour on and off, and probably functions as a centre for thirst control in the mammalian brain.
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