磷脂过氧化氢谷胱甘肽过氧化物酶
谷胱甘肽还原酶
谷胱甘肽
GPX4
谷胱甘肽过氧化物酶
生物化学
过氧化物酶
线粒体
GPX6型
化学
膜
线粒体内膜
磷脂
GPX3型
分馏
酶
色谱法
作者
Enrico Panfili,Gabriella Sandri,Lars Ernster
出处
期刊:FEBS Letters
[Wiley]
日期:1991-09-23
卷期号:290 (1-2): 35-37
被引量:71
标识
DOI:10.1016/0014-5793(91)81219-x
摘要
The distribution of glutathione reductase (GR), glutathione peroxidase (GPx) and phospholipid hydroperoxide glutathione peroxidase (PHGPx) in isolated rat brain mitochondria was investigated. using a fractionation procedure for the separation of inner and outer membranes, contact sites between the two membranes and a soluble fraction mainly originating from the mitochondrial matrix. The data indicate that GR and GPx are concentrated in the soluble fraction, with a minor portion of the two enzymes being associated with the contact sites. PHGPx is localized largely in the inner membrane. The possible functional significance of these findings is discussed.
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