Beta-Catenin–NF-κB Interactions in Murine Hepatocytes: A Complex to Die for

The p65/β-catenin complex in hepatocytes undergoes dynamic changes during TNF-α-induced hepatic injury and plays a critical role in NF-κB activation and cell survival. Modulation of β-catenin levels is a unique mode of regulating NF-κB activity and thus may present novel opportunities in devising therapeutics in specific hepatic injuries.