斯塔斯明
有丝分裂
紫杉醇
主轴装置
诺可达唑
微管
克隆形成试验
细胞生物学
生物
癌症研究
有丝分裂出口
细胞分裂
细胞凋亡
细胞
癌症
生物化学
细胞骨架
遗传学
作者
Camelia Iancu,Sucharita J. Mistry,Steven Arkin,George F. Atweh
出处
期刊:PubMed
日期:2000-07-01
卷期号:60 (13): 3537-41
被引量:31
摘要
Stathmin is an abundant cytosolic phosphoprotein that plays an important role in the regulation of cellular proliferation. Its major function is to promote depolymerization of the microtubules that make up the mitotic spindle. Taxol is an effective chemotherapeutic agent whose activity is mediated through stabilization of the microtubules of the mitotic spindle. We demonstrate that antisense inhibition of stathmin expression chemosensitizes K562 leukemic cells to the antitumor effects of Taxol and results in a synergistic inhibition of their growth and clonogenic potential. In the presence of stathmin inhibition, exposure to Taxol results in more severe mitotic abnormalities (hypodiploidy and multinucleation). This, in turn, results in increased apoptosis of the aneuploid cells during subsequent cell division cycles. This novel molecular-based therapeutic approach may provide an effective form of cancer therapy that would avoid the severe toxicities associated with the use of multiple chemotherapeutic agents with overlapping toxicity profiles.
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