Foreword. Preface. Poor-outcome bipolar disorders. Lithium prophylaxis of bipolar disorder in ordinary clinical conditions: patterns of long-term outcome. Syndromal and psychosocial outcome in bipolar disorder: a complex and circular relationship. New psychotherapies for bipolar disorder. Long-term outcome of anticonvulsants in affective disorders. Mixed-state bipolar disorders: outcome data from the NIMH Collaborative Program on the Psychobiology of Depression. Depression in the course of bipolar disorder. Comparison of open versus blinded studies in bipolar disorder. Bipolar disorder and comorbid substance use disorder. Alcoholism in bipolar disorder. Rapid-cycling bipolar affective disorder. Bipolar II disorder: the importance of hypomania. The paradox of anxiety syndromes comorbid with the bipolar illnesses. Psychosocial treatment of bipolar disorder in the public sector: Program for Assertive Community Treatment model. Summary of findings on the course and outcome of bipolar disorders. Index.