GSTP1公司
谷胱甘肽S-转移酶
氧化应激
谷胱甘肽
医学
自闭症
基因型
自闭症谱系障碍
人口
内科学
遗传学
生理学
精神科
生物
基因
生物化学
酶
环境卫生
作者
YO Oshodi,Oyesola Ojewunmi,TA Oshodi,GT Ijarogbe,OC Ogun,Olatunji F. Aina,Foluso Ebun Afolabi Lesi
出处
期刊:Nigerian Journal of Clinical Practice
日期:2017-01-01
卷期号:20 (9): 1161-1161
被引量:9
标识
DOI:10.4103/njcp.njcp_282_16
摘要
The role of oxidative stress has been identified in the development of autism spectrum disorder (ASD), and polymorphisms of glutathione S-transferase have been associated with some diseases linked to oxidative stress. Hence, we evaluated the serum levels of oxidative stress markers and investigated genetic polymorphisms of glutathione S-transferase associated with autism.Forty-two children clinically diagnosed with ASD using the Diagnostic and Statistical Manual for Mental Disorders (DSM-5) criteria and a clinical interview were included in the study. Twenty-three age-matched controls without any known genetic/developmental disorder were also recruited. Oxidative stress markers along with the genetic polymorphisms of glutathione S-transferase were determined.Reduced glutathione in ASD patients was significantly lower than the control (P = 0.008), whereas other oxidative stress markers measured were not significantly different in both the control and case populations. The frequencies of GSTT1 and GSTM1 null genotypes were lower among the controls compared with the cases, however, no association risk was observed. The observed risk of carrying Val/Val genotype among the cases was approximately six times that of the controls.Individuals with ASD showed a significant diminished level of reduced glutathione, however, the distribution of GSTT1, GSTM1, and GSTP1 polymorphisms was not found to be associated with autism in this study population.
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