Nanomedicine is now proposed as an alternative to classical way for diagnosis, imaging agents, delivery and targeting. For the past few decades, there has been a considerable research interest in the area of drug delivery using as different nanoscale carriers for small and large molecules including liposomes, nanoparticles, antibodies etc. There is an urgent need to improve the understanding of toxicological implications of nanomedicines. Particular health risk of nanotechnology application in nanomedicine is still unknown, but researchers are gradually putting up theories to prove that nanotechnology pose many threats to human health as well as the environment. The current mini review presents the pitfalls of growing nanomedicine with nanoscale properties.