雌激素
医学
更年期
雌激素受体
背景(考古学)
老化
长寿
炎症
人口
伤口愈合
生物信息学
内分泌学
生理学
内科学
老年学
生物
免疫学
乳腺癌
癌症
古生物学
环境卫生
作者
Holly N. Wilkinson,Matthew J. Hardman
出处
期刊:Maturitas
[Elsevier]
日期:2017-09-01
卷期号:103: 60-64
被引量:104
标识
DOI:10.1016/j.maturitas.2017.06.026
摘要
Combined advances in modern medical practice and increased human longevity are driving an ever-expanding elderly population. Females are particularly at risk of age-associated pathology, spending more of their lives in a post-menopausal state. Menopause, denoted by a rapid decline in serum sex steroid levels, accelerates biological ageing across the body’s tissues. Post-menopause physiological changes are particularly noticeable in the skin, which loses structural architecture and becomes prone to damage. The sex steroid most widely discussed as an intrinsic contributor to skin ageing and pathological healing is 17β-estradiol (or estrogen), although many others are involved. Estrogen deficiency is detrimental to many wound-healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment widely reverses these effects. Over recent decades, many of the molecular and cellular correlates to estrogen’s beneficial effect on normal skin homeostasis and wound healing have been reported. However, disparities still exist, particularly in the context of mechanistic studies investigating estrogen receptor signalling and its potential cellular effects. New molecular techniques, coupled with increased understanding of estrogen in skin biology, will provide further opportunities to develop estrogen receptor-targeted therapeutics.
科研通智能强力驱动
Strongly Powered by AbleSci AI