[PP.10.10] EARLY VASCULAR AGING SYNDROME PREVALENCE IN RUSSIAN POPULATION

Objective: Vascular age is the apparent age of the arteries that can be affected by lifestyle risk and genetic factors. Subjects whose vascular age is older than chronological age might have higher cardiovascular risk. The aim of our study was to estimate early vascular aging (EVA) syndrome prevalence in population-based sample of Saint-Petersburg inhabitants according to pulse wave velocity (PWV) and cardio-ankle vascular index (CAVI) assessment. Design and method: As a part of all-Russian epidemiology survey ESSE-RF random sampling of 1600 Saint-Petersburg inhabitants (25–65 years) stratified by age and sex was involved. In 452 randomly selected subjects simultaneously cardio-ankle vascular index (CAVI) was measured by VaSera VS-1500 (Fukuda, Japan) and carotid-femoral pulse wave velocity (cfPWV) was measured by SphygmoCor (Atcor, Australia). We used 2 definitions of EVA syndrome - if vascular age calculated from pressure independent stiffness index (CAVI) exceeded the biological age> = 4 years (EVAcavi); and if cfPWV exceeded 2SD for corresponding age group (EVApwv). Hypertension was considered if BP> = 140/90 mmHg or antihypertensive treatment, diabetes type 2 was considered as fasting glucose> = 7.0 mmol/l or treatment. Results: EVAcavi prevalence is much higher, than EVApwv (table 1). According to both criteria, there is an increase of EVA with age. Kappa index of criteria agreement was low – 0,09. Table 1. EVA prevalence according to CAVI and PWV criteria and ageConclusions: Prevalence of EVA syndrome detected by applanational tonometry or volume sphygmography has low agreement. It seems that carotid-femoral PWV criteria do not sensitive to detect EVA even in the oldest age group. At the same time, CAVI is a weak instrument to measure vascular stiffness.