药代动力学
化学
共价键
衍生工具（金融）
药理学
组合化学
肿瘤细胞
生物化学
弹头
立体化学
前药
癌症研究
共价结合
作者
Zhongcai Jin,Tongtong Wu,Shijie Tang,Yanggang Liu,Yuqi Ai,Qiang Wan,Yan Zhao,Shuang Yan,Jie Zeng,Naiguo Xing,Yang Liu,Lin Chen,Zhijun Zhou,Chen Y,Lin Qiu
标识
DOI：10.1021/acs.molpharmaceut.6c00249
摘要
Ga]Ga-DOTA-mFS-KERERG-FAP-2286 lies in its design as a derivative of the DOTA-FAP-2286 scaffold, incorporating a sulfur(VI) fluoride exchange (SuFEx)-based covalent warhead and a hydrophilic polypeptide. This modification is anticipated to alter the pharmacokinetic profile, leading to enhanced tumor uptake and retention, thereby improving clinical diagnostic accuracy.
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(2025-6-4)
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