Bi‐Target Nanomodulator for Glioma‐Associated Myeloid Cells Polarization by Inducing Pyroptosis and Regulating Tryptophan Metabolism to Reshape Immunosuppressive Microenvironment of IDH‐Mutant Gliomas

but also regulates tryptophan metabolism in GAM via the released CH, effectively overcoming the immunosuppressive effects of IDH-mutant gliomas. The bi-target synergistic regulation of GAM reshapes the immunosuppressive TME of IDH-mutant gliomas and offers a novel idea for immunotherapy of IDH-mutant gliomas.