STING-driven mitochondrial metabolism reverses cisplatin resistance via MDH2 desuccinylation in non-small cell lung cancer

This study uncovers a previously unrecognized STING/MDH2 desuccinylation feedback loop that integrates metabolic reprogramming with immune activation. The findings provide insights into the underlying mechanisms and identify STING and Succ-MDH2 (Lys 314) as potential therapeutic targets for developing effective strategies against cisplatin-resistant NSCLC.