Aromatasecy p450 expression and clinical application in the tissues of endometrial hyperplasia and atypical hyperplasia

Objective To study the value of aromatasecy P450 in the tissues of endometrial hyperplasia and atypical hyperplasia in clinical diagnosis and treatment.Methods The immunohistochemiscal S-P method techniques were amplified to study the expression of aromatasecy P450,estrogen receptor(ER)and progesterone receptor(PR)in the tissues of endometrial from the observed group of 116 cases,including 30 cases of simple endometrial hyperplasia,32 cases of complex endometrial hyperplasia and 54 cases of endometrial atypical hyperplasia and analysed the clinical processement of these cases.Results There was no the positive expression in the normal endometrial tissues.But the positive expressions of aromatasecy P450 were found in the tissues of endometrial hyperplasia(simple endometrial hyperplasia,complex endometrial hyperplasia and atypical hyperplasia).The rates of the positive expressions were 41.1%,46.1% and 73.2% respectively.There were significant relationships among fouth groups(χ2=46.69,P0.01).There were no relationship between the rates of the positive expressions of ER and PR and degree of the histological atypia.There were no relationship between the expressions rates of aromatasecy P450 and the expressions of ER and PR in endometrial hyperplasia(simple endometrial hyperplasia,complex endometrial hyperplasia and atypical hyperplasia.).Conclusion Aromatasecy P450 may be a factor that induces endometrial hyperplasia and carcinomatous changes.And it may become a biological marker in early carcinomatous changes in endometrial tissues.It indicates that the occurrence of endometrial hyperplasia had a relationship with estrogen stimulation in endometrium.The positive expressions of PR may be a prognostic factor in conservative treatmeat of endometrial hyperplasia.