Significance of cystatin c combing with retinol binding protein in diagnosis of early renal injury of diabetes patients

Objective:To investigate the value of combined detection of cystatin c(Cyc-C)and retinol binding protein(RBP)in diagnosis of early renal injury of diabetes patients.Methods:A total of 170 patients with diabetes mellitus and 75 healthy controls were enrolled in this study.The blood and urine samples were collected and immunoturbidimetricassays were used to detect serum Cyc-C and urinary RBP.Results:The serum level of Cyc-C and urinary RBP were both significantly higher in diabetes patients(all P0.01),comparing to healthy controls.What's more,serum Cyc-C and RBP were both significantly higher in patients with diabetic nephropathy than patients with simple diabetes(all P0.01).The positive rates of CycC and RBP in patients with simple diabetes were 21.79% and 32.05%,respectively;while the positive rate of combined detection was 46.15%.The positive rates of Cyc-C and RBP in patients with diabetic nephropathy were 89.13% and 91.30%,respectively;while the positive rate of combined detectiong was 97.83%.Conclusions:Serum Cyc-C and urinary RBP are sensitive markers for early renal injury of diabetes patients,and combined detection of these two markers can significantly up-regulate the positive rate of detection of early renal injury in diabetes patients.