Objective: To investigate the effect of DLF regimen chemotherapy on quality of life(QOL) in patients with esophageal cancer. Methods: All eligible patients were enrolled.The EORTC quality of life questionnaire(QLQ)-C30 and QLQ-OES18 were used to measure changes in QOL before and after the chemotherapy. Results: The mean scores such as OESDYS,OESRFX and PA decreased after the chemotherapy;the mean scores such as PF,CF,EF and global QOL decreased the second day after the chemotherapy,but before the second chemotherapy the mean scores these increased;the mean scores such as NV,FA and AP increased the second day after the chemotherapy,but before the second chemotherapy the meam scores decreased. Conclusion: DLF regimen chemotherapy improved QOL in patients with esophageal cancer.