Vibrational Circular Dichroism in Study of Stereochemistry of Chiral β-Biscarboline with N—O Functional Group

Vibrational circular dichroism( VCD) was applied for study of the absolute configuration of chiral axial bis-carboline with N—O function. The computational results exhibite that(-)-biscarboline derivative should have a S absolute configuration. At the same time,electronic circular dichroism( ECD) and optical rotation( OR) methods were also used to study its absolute configuration. The results show that the three diffe-rent conclusion from VCD,ECD and OR methods should give a same conclusion,namely,this(-)-biscarboline derivative should have a S absolute configuration.