[Objectives] Using the Dade behring original package fibrinogen(Fbg) reagent (Thrombin Reagent) evaluates the Pacific Hemostasis Fbg reagent(Thrombin 500) on sysmex CA-coagulant- meter [Methods]①Using the Dade behring Fbg reagent and the Pacific Hemostasis Fbg reagent measured the levels of Fbg in 20 normal control and 10 high levels of Fbg, 10 low levels of Fbg. analysis the relativity.at the same time measured the two company’s control.②Using the two company’s new dissolved Fbg reagent and dissolved 24 h Fbg reagent(stored at refrigerator) measured the levels of Fbg ,to compare the stability of reagent .(using the new buffer liquid that taked out from refrigerator).③Using the two company’s buffer liquid of room temperature places 24h and new buffer liquid of very day measured the levels of Fbg,to compare the stability of buffer liquid.(the Fbg reagent is new dissolved)[Re- sults] The Pacific Hemostasis Fbg reagent have good relativity compare with the Dade behring Fbg reagentr=0.992,P0.05, the stability of the Pacific Hemostasis dissolved 24h Fbg reagent equal to the stability of the Dade behring dissolved 24 h Fbg reagentr= 0.998,P0.05 , the Dade behring buffer liquid of room temperature places 24 h can make the average levels of Fbg descent 0.41 r=0.993,P0.01. the Pacific Hemostasis buffer liquid of room temperature places 24 h can make the average levels of Fbg de- scent 0.54,r= 0. 995,P 0. 01. The stability of the Pacific Hemostasis buffer liquid is not good as The stability of the Dade behring buffer liquid .[Conclusion] The cheaper Pacific Hemostasis Fbg reagent replace the Dade behring Fbg reagent on CA-coagu- lant-meter can get accurate result at the same time reducing the cost .