Objective To study the malaria epidemic characteristics and control measures, so as to control malaria and eradicate falciparum malaria in Guangxi Autonomous Region of China. Methods During attack phase integrated measures were taken to control falciparum malaria in natural villages which were classified according to the prevalence of malaria; post control of malaria, the major control measure was seeking and getting rid of the malaria infection source through examining the fever patients and the annul blood examination rate was up to 10%. Results The malaria morbidity in Guangxi was reduced from 296.7 to 0.07; during 1997-2001 a total of 6 241 011 fever patients and foci residents were examined and only 485 cases of vivax malaria were found out, but falciparum malaria was not discovered. Conclusion The measures were very effective for basically eliminating malaria and falciparum malaria in Guangxi.