发病机制
RNA剪接
计算生物学
医学
选择性拼接
生物
核糖核酸
生物信息学
计算机科学
癌症研究
遗传学
病理
基因
信使核糖核酸
作者
Amy Haseley Thorne,Webster K. Cavenee,Frank B. Furnari
出处
期刊:Medical research archives
[Knowledge Enterprises Journals]
日期:2015-01-22
被引量:1
摘要
Alternative splicing enables the generation of different proteins from a single gene, greatly increasing the use of genetic information. The resultant protein isoforms often have different biological properties effecting the phenotype of the cell in which it is expressed. Dysregulation of alternative splicing is a common occurrence in cancer and may lead to the formation of truncated or degraded proteins through the introduction of immature stop codons or nonsense mediated decay. Increasing evidence indicates that cancer-associated splicing variants play an important role in tumor initiation and progression. In this review, we summarize the evidence supporting the relevance of alternative splicing in glioblastoma multiforme (GBM). Specifically, we focus on the role of alternative splicing in GBM pathogenesis with an emphasis on the effect of aberrant alternative splicing of FGFR, GLI-1, and EGFR. The significance of exploiting alternatively spliced isoforms as potential biomarkers which may contribute to the development of diagnostic and prognostic methods, in addition to serving as molecular targets in GBM, will be discussed.
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