Objective To discuss the the correlation between local effect and the overall effect of three different moxibustion treatments.Methods Establishing acute hyperlipemia rat-models to compare rat Shenque acupoint skin gap junction connexin(connexin43,Cx43) expression with blood lipid regulation by respectively using warming moxibustion,ginger moxibustion and grain moxibustion.Results The differences were significant among three different moxibustion treatment groups with the model control group(P0.01).Conclusion Cx43 expression is related to the different moxibustion treatments,and the results are consisitent to the results of blood lipid regulation by different moxibustion treatments.