Comparision of Metoprolol Succinate Sustained-release Tablets and Metoprolol Tartrate Tablets on Cardiac Function in Patients with Chronic Congestive Heart Failure

Objective: To investigate the effect of Metoprolol succinate sustained-release tablets and Metoprolol tartrate tablets on cardiac in chronic congestive heart failure patients. Methods: 182 patients with clinical data, who suffered with chronic congestive heart failure were collected, and 67 cases were excluded. The patients were divided into 2 groups according to the different types of dosage forms: Metoprolol succinate sustained-release tablets group and Metoprolol Tartrate Tablets group. Patients in Metoprolol Tartrate Tablets group took 25mg-50mg Metoprolol Tartrate Tablets every day, while patients in the other group took 23.75-95mg metoprolol succinate sustained-release tablets every day. Average heart rate, LVDd, EF, BUN and Crea were measured. Results: Compared with Metoprolol Tartrate Tablets, Metoprolol succinate sustained-release tablets decreased average heart rate in chronic congestive heart failure patients(64.0±5.4 vs 69.5±7.6, P0.05). The two groups had no difference in LVDd, EF, BUN and Crea. Conclusions: Metoprolol succinate sustained-release tablets decreased average heart rate in chronic congestive heart failure patients compared with Metoprolol Tartrate Tablets. The effect on cardiac and renal function was equal.