Cross-specialty graduation design should be given attention and will exist longer in more specialties of colleges and universities.On the basis of practice of cross-specialty graduation design,forms and characteristics of cross-specialty graduation design,innovative projects with cross-specialty knowledge synthesized,innovative results with synthesized knowledge from teachers,and the innovation of graduation design with computer network are introduced.It is presented that innovation of cross-specialty graduation design is directed with theory of combinatorial innovation so that students have innovative ways and directions in graduation design.