Study developments on cyclization of piperazine and its derivatives from ethylenediamine

This paper presents the process in which piperazine or its derivatives are synthesized by using ethylenediamine or its derivatives.Combined with ethylene oxide,ethylene glycol,monoethanel-amine,and diethylenetriamine,respectively.Ethylenediamine can be used to synthesize piperazine in different routines,and ethylenediamine itself may cyclizate into piperazine.In addition,ethylenediamine or its diveratives,used as original reactions with other substances,can be used to produce the derivatives of piperazine through ethylenediamine series of synthesis reactions.Piperazine and its derivatives are important fine chemical materials and intermediates of medicines,and they have wide application.