Objective:To investigate the relationships between chronic infection of chlamydia pneumoniae and Coronary heart disease(CHD).Methods:The IgG and IgM antibodies against chlamydia pneumoniae in 32 cases of CHD and 32 cases of non-atherosclerosis confirmed by coronary angiography were detected by fluoroscopic immunoassay.Results:The CHD group had a significantly higher titer of antibodies against chlamydia pneumoniae than that of the non-atherosclerosis group(71.88% vs 25.00%,P0.01).Conclusions: There was a strong correlation between chronic infection of chlamydia pneumoniae and CHD.