氧化应激
活性氧
转录因子
细胞生物学
抗氧化剂
毒性
真菌毒素
氧化磷酸化
谷胱甘肽
KEAP1型
细胞凋亡
化学
生物
遗传毒性
药理学
程序性细胞死亡
活力测定
细胞毒性
DNA损伤
生物化学
基因
生物技术
有机化学
作者
Marta Justyna Kozieł,Karolina Kowalska,Agnieszka Wanda Piastowska-Ciesielska
标识
DOI:10.1007/s00204-021-02995-4
摘要
Nuclear factor erythroid 2-like 2 (Nrf2) is a transcription factor participating in response to cellular oxidative stress to maintain the redox balance. Generation of reactive oxygen species (ROS) and, in consequence, oxidative stress, are physiological as well as pathological processes which take place in almost all types of cells. Nrf2, in response to oxidative stress, activates expression and production of antioxidant enzymes to remove free radicals. However, the role of Nrf2 seems to be more sophisticated and its increased expression observed in cancer cells allows to draw a conclusion that its role is tissue-and condition-dependent. Interestingly, Nrf2 might also play a crucial role in response to environmental factors like mycotoxins. Thus, the aim of the study is to review the role of Nrf2 in cells exposed to most common mycotoxins to check if the Nrf2 signaling pathway serves as the main response element to mycotoxin-induced oxidative stress in human and animal cells and if it can be a target of detoxifying agents.
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