SLCO1B1型
医学
甲氨蝶呤
内科学
亚甲基四氢叶酸还原酶
肿瘤科
基因型
单核苷酸多态性
胃肠病学
作者
Manasawee Srisuttayasathien,Nutthada Areepium,Ruangsak Lertkhachonsuk
出处
期刊:Personalized Medicine
[Future Medicine]
日期:2021-02-10
卷期号:18 (2): 107-114
标识
DOI:10.2217/pme-2020-0089
摘要
Aim: The aim of this study was to explore the effects of ABCB1 and SLCO1B1 gene polymorphisms and the methotrexate (MTX) treatment response in patients with low-risk gestational trophoblastic neoplasia (GTN). Materials & methods: Low-risk GTN patients who received MTX as a first-line single agent were enrolled. DNA was extracted from peripheral blood samples from 18 patients and assessed for ABCB1 C3435T and SLCO1B1 T521C. Results:ABCB1 C3435T and SLCO1B1 T521C polymorphisms were not associated with the MTX response or toxicity in Thai patients Conclusion: The selected ABCB1 and SLCO1B1 polymorphism do not predict the risk of MTX resistance in low-risk GTN.
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