光热治疗
纳米团簇
纳米棒
材料科学
光热效应
纳米技术
生物相容性
表面等离子共振
纳米复合材料
介孔二氧化硅
介孔材料
化学工程
纳米颗粒
化学
有机化学
冶金
催化作用
工程类
作者
Qianqian Duan,Min Yang,Boye Zhang,Yang Li,Yixia Zhang,Xiaoning Li,Jianming Wang,Wendong Zhang,Shengbo Sang
标识
DOI:10.1016/j.jphotobiol.2020.112111
摘要
Photothermal therapy (PTT) is a non-invasive therapy that is widely used in cancer treatment. Gold nanorods (AuNRs) are particularly suitable as a photothermal reagent due to their unique localized surface plasmon resonance (LSPR) properties. However, bare gold nanorods are not stable enough during radiation to collect enough energy to kill tumor cells. In addition, they showed some biologically toxic originated from the poor colloidal stability and surfactants cetyltrimethyl ammonium bromide (CTAB), making it difficult to apply them directly to clinical research. To solve these problems, a novel nanocomposite was structured by coating silica shell and gold nanocluster on the outer layer of the gold nanorod ([email protected]2@AuNCs). Compared with the bare gold nanorod, the nanocomposite with the core-shell structure showed superior photothermal effect. The photothermal conversion temperature reached 63 °C under a lower irradiation power. The photothermal conversion efficiency was enhanced to 77.6%. Its photothermal performance remained constant after five cycles of near-infrared laser irradiation, indicating excellent photothermal stability. In vitro cell imaging experiments show that [email protected]2@ AuNCs can effectively enter tumor cells. By 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) analysis, cancer cells can be effectively killed when exposed to a near-infrared laser. During the synthesis process, the silica and gold nanoclusters replaced the toxic CTAB molecular layer on the surface of AuNRs. Therefore, [email protected]2@AuNCs has good biocompatibility and fluorescence characteristics. These results suggest that such [email protected]2@AuNCs nanocomposite shows great potential in imaging guided photothermal therapy for cancer.
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