吴茱萸碱
胶束
化学
Zeta电位
肝纤维化
溶解度
粒径
纤维化
药理学
色谱法
材料科学
纳米技术
医学
纳米颗粒
内科学
水溶液
有机化学
物理化学
作者
Yingguang Deng,Xue‐Li Lyu,Yuexin Zhu,Shichang Zhang,Sijia Liu,Boxin Zhao,Guofeng Li
出处
期刊:PubMed
日期:2020-07-01
卷期号:45 (13): 3136-3143
被引量:1
标识
DOI:10.19540/j.cnki.cjcmm.20200424.304
摘要
This study aimed to prepare evodiamine-glycyrrhizic acid(EVO-GL) micelles to enhance the anti-hepatic fibrosis activity of evodiamine. Firstly, EVO-GL micelles were prepared with use of thin film dispersion method. With particle size, encapsulation efficiency, loading capacity of micelles and the solubility of evodiamine as the indexes, the effect of different factors on micelles was observed to screen the optimal preparation methods and process. Then the pharmaceutical properties and the therapeutic effects of EVO-GL micelles prepared by optimal process were evaluated on CCl_4-induced hepatic fibrosis. The results showed that the micelles prepared by the thin film dispersion method had an even size, with an average particle size of(130.80±12.40)nm, Zeta potential of(-41.61±3.12) mV, encapsulation efficiency of 91.23%±1.22%, drug loading of 8.42%±0.71%, high storage stability at 4 ℃ in 3 months, and slow in vitro release. Experimental results in the treatment of CCl_4-induced hepatic fibrosis in rats showed that EVO-GL micelles had a synergistic anti-hepatic fibrosis effect, which significantly reduced the liver function index of hepatic fibrosis rats. In conclusion, the EVO-GL micelles prepared with glycyrrhizic acid as a carrier would have a potential application prospect for the treatment of hepatic fibrosis.
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