邻近连接试验
结扎
计算生物学
淋巴瘤
补语(音乐)
计算机科学
生物
分子生物学
免疫学
生物化学
基因
受体
表型
互补
出处
期刊:Methods in molecular biology
日期:2019-01-01
卷期号:: 363-370
被引量:4
标识
DOI:10.1007/978-1-4939-9151-8_18
摘要
Many methods exist to study oncogenic signaling in lymphoma cells, each with certain strengths and weaknesses. The proximity ligation assay (PLA) is a technique used to examine protein-protein interactions in situ. PLA offers many advantages over traditional biochemical approaches to signaling in that it can detect both transient interactions, which are hard to capture otherwise, as well as protein interactions within large supramolecular signaling platforms that are often intractable to traditional biochemical methodologies. In addition, PLA can be adapted for use in lymphoma biopsy samples to translate findings from the lab. Implementation of PLA can complement many types of lymphoma research, and the methods presented herein can be adapted to a number of experimental settings.
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