日本使徒
生物
海参
黄杆菌科
基因组
微生物群
微生物种群生物学
肠道菌群
拟杆菌
16S核糖体RNA
生态学
细菌
基因
生物化学
遗传学
作者
Hongxia Zhang,Qing Wang,Jianmin Zhao,Shilin Liu,Libin Zhang,Ye Zhao,Hongsheng Yang,Lina Sun
出处
期刊:Genomics
[Elsevier]
日期:2020-11-01
卷期号:112 (6): 5012-5020
被引量:8
标识
DOI:10.1016/j.ygeno.2020.09.017
摘要
The intestinal microbiota may play important roles in regenerating intestine of the sea cucumber Apostichopus japonicus, the underlying mechanism remains unclear. In the present study, a germ-free sea cucumber model was developed, and the intestinal microbial differentiation of faster and slower regenerating A. japonicus individuals during intestine regeneration was analyzed. The results revealed that depletion of the intestinal microbiota resulted in elevated abundance of the potential key players Flavobacteriaceae and Rhodobacteraceae during intestine regeneration and thus promoted the intestine regeneration rate of A. japonicus. Metagenomic analysis revealed that the increased abundance of Flavobacteriaceae elevated the enrichment of genes associated with carbohydrate utilization, whereas the abundant Rhodobacteraceae-enriched genes were associated with polyhydroxybutyrate production. We identified microbiota abundance as a key driver of microbial community alterations, especially beneficial microbiota members, in the developing intestine of A. japonicus. This study provides new insights into the mechanism of host-microbiota interactions related to organ regeneration.
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