肝素
抗凝剂
药理学
动物健康
牲畜
化学
生物技术
医学
生物
生物化学
外科
兽医学
生态学
作者
Sultan Nacak Baytaş,Robert J. Linhardt
标识
DOI:10.1016/j.drudis.2020.09.011
摘要
Heparin is a naturally occurring glycosaminoglycan from livestock, principally porcine intestine, and is clinically used as an anticoagulant drug. A limitation to heparin production is that it depends on a single animal species and potential problems have been associated with animal-derived heparin. The contamination crisis in 2008 led to a search for new animal sources and the investigation of non-animal sources of heparin. Over the past 5 years, new animal sources, chemical, and chemoenzymatic methods have been introduced to prepare heparin-based drugs. In this review, we describe advances in the preparation and synthesis of heparin and related products.
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