医学
托珠单抗
2019年冠状病毒病(COVID-19)
细胞因子释放综合征
病危
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
2019-20冠状病毒爆发
白细胞介素6
内科学
危重病
单克隆抗体
疾病严重程度
细胞因子
单克隆
免疫学
抗体
病毒学
疾病
传染病(医学专业)
爆发
作者
Shruti Gupta,Wei Wang,Salim S. Hayek,Lili Chan,Kusum S. Mathews,Michal L. Melamed,Samantha K. Brenner,Amanda K. Leonberg‐Yoo,Edward J. Schenck,Jared Radbel,Jochen Reiser,Anip Bansal,Anand Srivastava,Yan Zhou,Diana G. Finkel,Adam Green,Mary C. Mallappallil,Anthony J. Faugno,Jingjing Zhang,Juan Carlos Q. Velez
标识
DOI:10.1001/jamainternmed.2020.6252
摘要
Among critically ill patients with COVID-19 in this cohort study, the risk of in-hospital mortality in this study was lower in patients treated with tocilizumab in the first 2 days of ICU admission compared with patients whose treatment did not include early use of tocilizumab. However, the findings may be susceptible to unmeasured confounding, and further research from randomized clinical trials is needed.
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