核糖体分析
计算生物学
蛋白质组
生物
转录组
基因组
系统生物学
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核糖体
蛋白质组学
翻译(生物学)
核糖核酸
生物信息学
遗传学
信使核糖核酸
基因表达
基因
肽序列
作者
Rui Vitorino,Sofia Guedes,Francisco Amado,Manuel A. S. Santos,Nobuyoshi Akimitsu
标识
DOI:10.1007/s00018-020-03740-3
摘要
Micropeptides are small polypeptides coded by small open-reading frames. Progress in computational biology and the analyses of large-scale transcriptomes and proteomes have revealed that mammalian genomes produce a large number of transcripts encoding micropeptides. Many of these have been previously annotated as long noncoding RNAs. The role of micropeptides in cellular homeostasis maintenance has been demonstrated. This review discusses different types of micropeptides as well as methods to identify them, such as computational approaches, ribosome profiling, and mass spectrometry.
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