番石榴属
抗真菌
萜类
萜烯
化学
立体化学
三萜类
传统医学
生物
植物
医学
微生物学
作者
Xiaocong Liu,Dongmei Lin,Min Liu,Min Zhang,Qiang Li,Jian Wang,Liyan Xu,Yuan Gao,Jian Yang
出处
期刊:China journal of Chinese materia medica
[China Journal of Chinese Materia Medica]
日期:2021-08-01
卷期号:46 (15): 3877-3885
被引量:2
标识
DOI:10.19540/j.cnki.cjcmm.20210517.202
摘要
Twenty-six compounds, including sixteen meroterpenoids(1-16), a triterpenoid(17), four terpenoid derivatives(18-21), and five aromatic compounds(22-26), were isolated from the leaves of Psidium guajava. Their structures were identified by spectroscopic analyses including NMR and MS. Compounds 21-26 were obtained from plants of Psidium for the first time. Based on the structure,(R)-2-ethylhexyl 2H-1,2,3-triazole-4-carboxylate(24 a), an α-glucosidase inhibitor recently isolated from Paramignya trimera, should be revised as compound 24. Meroterpenoids 1-16 were evaluated for their antitumor and antifungal activities. Meroterpenoids psiguajadial D(4), guapsidial A(5), 4,5-diepipsidial A(7), guadial A(14), and guadial B(15) showed cytotoxicities against five human tumor cell lines(HL-60, A-549, SMMC-7721, MCF-7, and SW-480), among which 5 was the most effective with an IC_(50) of 3.21-9.94 μmol·L~(-1).
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