泊沙康唑
毛霉病
医学
抗真菌
外科清创术
清创术(牙科)
外科
伊曲康唑
挽救疗法
重症监护医学
两性霉素B
皮肤病科
化疗
作者
Julie M. Steinbrink,Marisa H. Miceli
标识
DOI:10.1016/j.idc.2021.03.009
摘要
Mucormycosis is a rare but aggressive fungal disease that mainly affects patients with poorly controlled diabetes mellitus and those who are severely immunocompromised, including patients with hematological malignancies and solid organ transplant recipients. Early recognition of infection is critical for treatment success, followed by prompt initiation of antifungal therapy with lipid formulation amphotericin B. Posaconazole and isavuconazole should be used for stepdown and salvage therapy. Surgical debridement is key for tissue diagnosis and treatment and should be pursued urgently whenever possible. In addition to surgery and antifungal therapy, reverting the underlying risk factor for infection is important for treatment response.
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