烷基
化学
基质(水族馆)
组合化学
有机化学
氟化物
叠氮化物
范围(计算机科学)
计算机科学
生物
生态学
无机化学
程序设计语言
作者
Juncheng Guo,Xiu Wang,Chuanfa Ni,Xiaolong Wan,Jinbo Hu
标识
DOI:10.1038/s41467-022-30132-x
摘要
Abstract Direct deoxyazidation of alcohols with NaN 3 is a straightforward method for the synthesis of widely used alkyl azides in organic chemistry. However, known methods have some limitations such as high reaction temperatures and narrow substrate scope. Herein, a general and practical method for the preparation of alkyl azides from alcohols using NaN 3 has been developed. N -tosyl-4-chlorobenzenesulfonimidoyl fluoride (SulfoxFluor) plays an important role in this deoxyazidation process, which converts a broad range of alcohols into alkyl azides at room temperature. The power of this deoxyazidation protocol has been demonstrated by successful late-stage deoxyazidation of natural products and pharmaceutically relevant molecules.
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